Abstract

This contribution provides complementary experimental data of solubility (y2, molar fraction) of solid 1, 3-dimethyl-7H-purine-2, 6-dione (theophylline) in supercritical CO2 as a function of temperature (313 K =T =333 K) and pressure (10 MPa =P =44 MPa). A static-analytic methodology was used with standard deviations from average solubility measurements of =38 % and with estimated inherit errors =25 %. The solubility of theophylline increased with the CO2 density from 0.33·10-5 mol·mol-1at 797.2 kg·m -3 (313 K, 16 MPa) to 3.3 middot;10-5 mol · mol-1 at 890.2 kg · m-3 (333 K, 40 MPa). The solubility increased with pressure and temperature. Experimental solubilities were correlated with a density-based model with three adjustable parameters, which was valid for solvent densities in the range of (400 to 950) kg·m-3. © 2009 American Chemical Society.