Article ISI SCOPUS
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE  (2020)

Extracellular vesicles derived from fat-laden hepatocytes undergoing chemical hypoxia promote a pro-fibrotic phenotype in hepatic stellate cells

Hernandez, Alejandra; Reyes, Daniela; Geng, Yana; Arab, Juan P.; CABRERA-GARCIA, DANIEL ALEJANDRO; Sepulveda, R.; Solis, Nancy; Buist-Homan, Manon; ARRESE-JIMENEZ, MARCO ANTONIO; Moshage, Han

Abstract

Background: The transition from steatosis to non-alcoholic steatohepatitis (NASH) is a key issue in non-alcoholic fatty liver disease (NAFLD). Observations in patients with obstructive sleep apnea syndrome (OSAS) suggest that hypoxia contributes to progression to NASH and liver fibrosis, and the release of extracellular vesicles (EVs) by injured hepatocytes has been implicated in NAFLD progression.

Más información

Título según WOS: ID WOS:000559983700018 Not found in local WOS DB
Título según SCOPUS: ID SCOPUS_ID:85086604446 Not found in local SCOPUS DB
Título de la Revista: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
Volumen: 1866
Fecha de publicación: 2020
DOI:

10.1016/J.BBADIS.2020.165857
Notas: ISI, SCOPUS