Hepatitis C virus quasispecies in plasma and peripheral blood mononuclear cells of treatment naive chronically infected patients

Vera-Otarola, J; Barría MI; León U; Marsac D.; Carvallo, P.; Soza A.; Lopez-Lastra, M

Abstract

Peripheral blood mononuclear cells (PBMCs) from 45 treatment naïve, HIV-negative, chronically hepatitis C virus (HCV)-infected patients were analyzed for the presence of HCV RNA. Viral RNA was detected in 73% of the studied patients. Single-strand conformation polymorphism assays and sequence analysis of the HCV 5'untranslated regions amplified from RNA recovered from both Plasma and PBMCs suggested virus compartmentalization in 57.6% of patients studied. In summary, our study presents evidence that HCV RNA can be found in PBMCs of treatment naïve chronically infected patients that are not immunocompromised or co-infected with the human immunodeficiency virus. © 2009 The Authors.

Más información

Título según WOS: Hepatitis C virus quasispecies in plasma and peripheral blood mononuclear cells of treatment naive chronically infected patients
Título según SCOPUS: Hepatitis C virus quasispecies in plasma and peripheral blood mononuclear cells of treatment naïve chronically infected patients
Título de la Revista: JOURNAL OF VIRAL HEPATITIS
Volumen: 16
Número: 9
Editorial: Wiley
Fecha de publicación: 2009
Página de inicio: 633
Página final: 643
Idioma: English
URL: http://doi.wiley.com/10.1111/j.1365-2893.2009.01112.x
DOI:

10.1111/j.1365-2893.2009.01112.x

Notas: ISI, SCOPUS