Abstract

Severe burn patients undergo major pathophysiological changes. There are 2 major phases: hypodynamic and hyperdynamic. Total intravenous anesthesia, in target control infusion mode is an alternative during the hyperdynamic phase, but there is little evidence of the predictive capacity of the models been used. Given such uncertainty, plasma propofol concentrations were measured in a cohort of severe burn patients admitted to the Hospital de Urgencia Asistencia Pública and compared with the concentrations predicted for the Marsh and Schnider models. To determine performance, bias and absolute error of the model were calculated. 112 plasma concentration measurements belonging to 11 patients were evaluated. For Schnider, the bias was -8%, and the overall error was 48.7%. For Marsh, the bias was -13.5% and the overall error 40.5%. This study allows to validate the use of the Marsh model in severe burns patientes, in their hyperdynamic phase.