Endocrine effects of lithium: Pathophysiological mechanisms and clinical implications
Abstract
Lithium carbonate has a narrow therapeutic range capable of producing various adverse effects; despite this fact, it is used as first-line therapy in patients with bipolar disorder (BD) thanks to its high effectiveness. Among its adverse events are several conditions at the endocrine level, such as hypothyroidism, hyperthyroidism, hypercalcemia, hyperparathyroidism, and nephrogenic diabetes insipidus. The adherence to current guidelines for monitoring those events is low. The objective of this review is to provide insight into the pathophy- siological mechanisms of the endocrine effects of lithium and give recommendations based on the current literature for the monitoring and treatment of these conditions.
Más información
Título según WOS: | Endocrine effects of lithium: Pathophysiological mechanisms and clinical implications |
Título según SCIELO: | Efectos endocrinológicos del litio: Mecanismos fisiopatológicos e implicancias clínicas |
Título de la Revista: | REVISTA MEDICA DE CHILE |
Volumen: | 152 |
Número: | 4 |
Editorial: | Sociedad Médica de Santiago |
Fecha de publicación: | 2024 |
Página de inicio: | 498 |
Página final: | 507 |
Idioma: | es |
DOI: |
10.4067/s0034-98872024000400498 |
Notas: | ISI, SCIELO |