Article ISI SCIELO SCOPUS
Journal of the Chilean Chemical Society  (2009)

SYNTHESIS OF CONFORMATIONALLY RESTRICTED N-{4-[4-(4,7-DIMETHOXY-BENZO[b]THIOPHENE-2-CARBONYL)-1-PIPERAZINYL]-PHENYL}-ARYLCARBOXAMIDES POTENTIAL LIGANDS WITH 5-HT1A BINDING AFFINITY

Pessoa-Mahana H.; González C; Araya-Maturana, R; Saitz C.; Pessoa-Mahana, CD

Abstract

New benzothiophene arylpiperazine derivatives 7 (a-f) were synthesized as potential serotoninergic agents with 5-HT1A receptor affinity. Preparation of the derivatives was performed by reaction of 1-(4-aminophenyl)-4-[(4,7-dimethoxy-1-benzothien-2-yl)carbonyl] piperazine (6) with a series of substituted aroyl chlorides.

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Título según WOS: SYNTHESIS OF CONFORMATIONALLY RESTRICTED N-{4-[4-(4,7-DIMETHOXY-BENZO[b]THIOPHENE-2-CARBONYL)-1-PIPERAZINYL]-PHENYL}-ARYLCARBOXAMIDES POTENTIAL LIGANDS WITH 5-HT1A BINDING AFFINITY
Título según SCOPUS: Synthesis of conformationally restricted N-{4-[4-(4,7-dimethoxy-benzo[b]thiophene-2-carbonyl)-1-piperazinyl]-phenyl}-arylcarboxamides potential ligands with 5-ht1A binding affinity
Título según SCIELO: SYNTHESIS OF CONFORMATIONALLY RESTRICTED N-{4-[4-(4,7-DIMETHOXY-BENZO[b]THIOPHENE-2-CARBONYL)-1-PIPERAZINYL]-PHENYL}-ARYLCARBOXAMIDES POTENTIAL LIGANDS WITH 5-HT1A BINDING AFFINITY
Título de la Revista: Journal of the Chilean Chemical Society
Volumen: 54
Número: 2
Editorial: SOC CHILENA QUIMICA
Fecha de publicación: 2009
Página de inicio: 147
Página final: 150
Idioma: English
DOI:

10.4067/S0717-97072009000200011
Notas: ISI, SCIELO, SCOPUS