Article ISI SCOPUS
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS  (2009)

The Ski protein can inhibit ligand induced RAR alpha and HDAC3 degradation in the retinoic acid signaling pathway

Zhao, HL; Ueki, N; Marcelain, K; Hayman, MJ

Abstract

Recent data has implicated the Ski protein as being a physiologically relevant negative regulator of signaling by retinoic acid (RA). The mechanism by which Ski represses RA signaling is unknown. Co-immunoprecipitation and immunofluorescence assay showed that Ski and RARa are in the same complex in both the absence and presence of RA, which makes Ski different from other corepressors. We determined that Ski can stabilize RARa and HDAC3. These results suggest that Ski represses RA signaling by stabilizing corepressor complex. © 2009 Elsevier Inc. All rights reserved.

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Título según WOS: The Ski protein can inhibit ligand induced RAR alpha and HDAC3 degradation in the retinoic acid signaling pathway
Título según SCOPUS: The Ski protein can inhibit ligand induced RAR? and HDAC3 degradation in the retinoic acid signaling pathway
Título de la Revista: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volumen: 383
Número: 1
Editorial: ACADEMIC PRESS INC ELSEVIER SCIENCE
Fecha de publicación: 2009
Página de inicio: 119
Página final: 124
Idioma: English
URL: http://linkinghub.elsevier.com/retrieve/pii/S0006291X09006275
DOI:

10.1016/j.bbrc.2009.03.141
Notas: ISI, SCOPUS