Association Between p53 codon 72 Genetic Polymorphism and Tobacco Use and Lung Cancer Risk

Caceres, DD; Quinones, LA; Schroeder, JC; Gil, LD; Irarrazabal, CE

Abstract

Lung cancer (LCa) is the leading cause of death by cancer in men. Genetic and environmental factors play a synergistic role in its etiology. We explore in 111 lung cancer cases and 133 unrelated noncancer controls the gene-environment interaction (G × E) between p53cd72 polymorphism variants and smoking and the effect on LCa risk in two kinds of case-control designs. We assessed the interaction odds ratio (IOR) using an adjusted unconditional logistic model. We found a significant and positive interaction association between Proallele carriers and smoking habits in both case-control and case-only designs: IOR = 3.90 (95% confidence interval [CI] = 1.10-13.81) and 3.05 (95% CI = 1.63-5.72), respectively. These exploratory results suggest a synergistic effect of the smoking habit and the susceptibility of the Pro allele on lung cancer risk compared with each risk factor alone. © 2008 Springer Science+Business Media, LLC.

Más información

Título según WOS: Association Between p53 codon 72 Genetic Polymorphism and Tobacco Use and Lung Cancer Risk
Título según SCOPUS: Association between p53 codon 72 genetic polymorphism and tobacco use and lung cancer risk
Título de la Revista: LUNG
Volumen: 187
Número: 2
Editorial: Springer
Fecha de publicación: 2009
Página de inicio: 110
Página final: 115
Idioma: English
URL: http://link.springer.com/10.1007/s00408-008-9133-3
DOI:

10.1007/s00408-008-9133-3

Notas: ISI, SCOPUS