Unveiling the potential of HS-1793: a review of its anticancer properties and therapeutic promise

Capo, Xavier; Jimenez-Garcia, Manuel; Sharopov, Farukh; Fokou, Patrick Valere Tsouh; Martorell, Miquel; Aldahish, Afaf Ahmed; Pezzani, Raffaele; Sharifi-Rad, Javad; Calina, Daniela

Abstract

HS-1793 is a novel derivative of resveratrol, a compound known for its numerous beneficial effects, including anticancer activity, anti-inflammatory response, antimicrobial, antiaging, anti-cardiovascular disease activity, neuroprotective activity, etc. Despite its wide and interesting properties, resveratrol suffers from a crucial flaw because it is low bioavailable. For this reason, many other derivatives were explored and among them, HS-1793 has caught the attention of researchers. HS-1793 is a synthetic derivative of resveratrol discovered in 2007 that has been shown to have anti-cancer and anti-inflammatory properties. In addition, the compound showed a positive profile in metabolic processes, with adequate pharmacokinetics and pharmacodynamics. This review highlights current research on HS-1793, evaluating in vitro and in vivo works and lays the foundation for novel explorative trials in human diseases.

Más información

Título según WOS: ID WOS:001425281800001 Not found in local WOS DB
Título de la Revista: FUTURE MEDICINAL CHEMISTRY
Volumen: 16
Número: 21
Editorial: TAYLOR & FRANCIS LTD
Fecha de publicación: 2024
Página de inicio: 2301
Página final: 2311
DOI:

10.1080/17568919.2024.2424150

Notas: ISI