Abstract

This research focuses on analyzing the information reported by the RCSB Protein Data Bank (RCSB PDB) for the molecular target of Factor Xa (FXa), a key enzyme in the human coagulation cascade. This biocatalytic process called cascade comprises thirteen factors, proteins, and cofactors activated consecutively in dominotype reactions. The cascade model is proposed based on two activation pathways: the intrinsic pathway initiated by stimuli from the damaged surface of the blood vessel epithelium and the extrinsic pathway initiated by trauma to the blood vessel tissue. These two pathways converge at a standard point Factor X (FX), whose purpose is to convert fibrinogen monomers into an insoluble fibrin network, agglutinating blood material, red blood cells, and platelets to form a stable clot that stops the caused bleeding. © 2023 by the authors.