Coprocessing Thermosensitive and Poorly Soluble Compounds via Spray-Freeze Microencapsulation to Enable Therapeutic Inhalation Delivery for Chronic Lung Infections

Bahamóndez Cañas, Tania Francisca

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Fecha de publicación: 2025
Objetivos: Engineer inhalable gelatin/DPPC microcapsules and microspheres by SD or SFD. Co-encapsulate ciprofloxacin,resolvin E1 and verbascoside to tackle infection, inflammation and tissue damage in chronic lung disease. Validate antimicrobial, anti-inflammatory and regenerative efficacy in 2 or3D cell model
Instrumento: Fondecyt Regular
Año de Inicio/Término: 2025-2028
Financiamiento/Sponsor: CONICYT
Rol del Usuario: COINVESTIGADOR(A)
DOI:

11190987

Notas: Success would deliver the first inhalable tri-therapy that clears P. aeruginosa biofilms, resolves inflammation and repairs tissue in one dose, cutting antibiotic load, boosting patient survival, and positioning Chile at the forefront of pulmonary medicine.