Coprocessing Thermosensitive and Poorly Soluble Compounds via Spray-Freeze Microencapsulation to Enable Therapeutic Inhalation Delivery for Chronic Lung Infections
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Fecha de publicación: | 2025 |
Objetivos: | Engineer inhalable gelatin/DPPC microcapsules and microspheres by SD or SFD. Co-encapsulate ciprofloxacin,resolvin E1 and verbascoside to tackle infection, inflammation and tissue damage in chronic lung disease. Validate antimicrobial, anti-inflammatory and regenerative efficacy in 2 or3D cell model |
Instrumento: | Fondecyt Regular |
Año de Inicio/Término: | 2025-2028 |
Financiamiento/Sponsor: | CONICYT |
Rol del Usuario: | COINVESTIGADOR(A) |
DOI: |
11190987 |
Notas: | Success would deliver the first inhalable tri-therapy that clears P. aeruginosa biofilms, resolves inflammation and repairs tissue in one dose, cutting antibiotic load, boosting patient survival, and positioning Chile at the forefront of pulmonary medicine. |