Cs2CO3-Catalyzed Rauhut-Currier-Type Reaction for the Synthesis of 2,3-Dihydrobenzo[b]oxepin Derivatives

Lopez, Roger; Jamis-Oliva, Omar; LUHR-SIERRA, SUSAN; GALDAMEZ-SILVA, ANTONIO CESAR; Gallardo-Fuentes, S.; Vilches-Herrera, Marcelo

Abstract

The synthesis of fused benzoxepines relies on the use of complex substrates and methodologies. Herein, we report our experimental and theoretical findings about an unprecedented Rauhut-Currier-type reaction catalyzed by Cs2CO3 to access these important compounds. The developed methodology avoids the use of phosphine- or amine-based catalysts and additives. The reaction can be performed under microwave irradiation and proceeds with complete chemoselectivity.

Más información

Título según WOS: Cs2CO3-Catalyzed Rauhut-Currier-Type Reaction for the Synthesis of 2,3-Dihydrobenzo[b]oxepin Derivatives
Volumen: 89
Número: 22
Fecha de publicación: 2024
Página de inicio: 16401
Página final: 16405
Idioma: English
DOI:

10.1021/acs.joc.4c01544

Notas: ISI