Brain Natriuretic Peptide (BNP) Produced by the Human Chorioamnion May Mediate Pregnancy Myometrial Quiescence

Carvajal, JA; Delpiano, AM; Cuello, MA; Poblete, JA; Casanello, PC; Sobrevia, LA; Weiner, CP

Abstract

We aim to demonstrate that Brain Natriuretic Peptide (BNP) is synthesized and released from the fetal membranes and mediates pregnancy myometrial quiescence. Myometrium and fetal membranes (FM) were obtained from term and preterm pregnancies at the time of cesarean section, either in labor or not in labor. BNP was measured in term and preterm FM, in culture cells, and conditioned media. We found BNP (but not ANP or CNP) inhibited contractions of preterm, but not term, human myometrium. BNP (both protein and mRNA) was detected in all tissues, conditioned media and cultured cells. BNP was higher in samples from preterm women not in labor compared to those at term not in labor. BNP concentrations were significantly reduced in women in spontaneous preterm labor. We conclude that locally produced BNP may be involved in generating myometrial quiescence during pregnancy. Further, a premature decrease of BNP production may cause preterm labor. © 2009 by the Society for Gynecologic Investigation.

Más información

Título según WOS: Brain Natriuretic Peptide (BNP) Produced by the Human Chorioamnion May Mediate Pregnancy Myometrial Quiescence
Título según SCOPUS: Brain Natriuretic Peptide (BNP) produced by the human chorioamnion may mediate pregnancy myometrial quiescence
Título de la Revista: REPRODUCTIVE SCIENCES
Volumen: 16
Número: 1
Editorial: SAGE PUBLICATIONS INC
Fecha de publicación: 2009
Página de inicio: 32
Página final: 42
Idioma: English
URL: http://rsx.sagepub.com/cgi/doi/10.1177/1933719108324137
DOI:

10.1177/1933719108324137

Notas: ISI, SCOPUS