Abstract

This study aimed to investigate autoregressive and lagged associations over 2 years between frailty, depression and quality of life, and to examine sex differences in these longitudinal associations among European men and women aged ?50 years. The analyses included 10,077 individuals (5589 women) from 12 European countries. Women attested to a higher frailty and depression score and lower quality of life than men. For both sexes, frailty and depression correlated positively cross-sectionally and longitudinally (2 years later), while quality of life correlated negatively with frailty and depression cross-sectionally and longitudinally. With regard to lagged associations, for both men and women, frailty proved to be a predictor of depression 2 years later. In turn, depression did not predict frailty and quality of life 2 years later in women, but it did among men. © The Author(s) 2025.