Abstract

Shannon entropy data were obtained from whole genome sequences of SARS-CoV-2 virus from COVID-19 positive patients from nasopharyngeal and tracheal aspirate samples, these sequences were downloaded from the NCBI public database. The study included 57 genomic sequences of the SARS-CoV-2 virus. A total of 57 samples ( n = 30 oronasopharyngeal and n = 27 tracheal aspirates) underwent bioinformatics-based analysis with the objective of determining the extent of viral variability. These sequences were used to perform a genetic variability analysis of the virus with the H(x) function of the BioEdit program and using the Wuhan-Hu-1 reference genome. The generated Shannon entropy data were filtered to comparatively determine the magnitudes of genetic variability between sequences from nasopharyngeal and tracheal aspirate samples using an R script.