Abstract

--- - Objectives. Head and neck mucosal melanoma (HNMM) is a rare disease with a poor prognosis. The aim of this research was to analyze clinical characteristics and prognostic factors in a Latin American cohort. - Study Design. A retrospective chart review of patients with HNMM treated between 2008 and 2019 was conducted. Demographic characteristics, tumor characteristics, surgical treatment, adjuvant therapy, and oncologic outcomes were recorded. - Results. Twenty HNMMs were identified; 60% were in men. The most frequent primary location was the nasal cavity (10; 50%). Regional disease was uncommon and limited to the oral cavity. The median overall survival was 29 months; the 3- and 5-year overall survival rates were 37.2% and 26.6%, respectively. Univariate analysis revealed that predictors of a worse overall survival were paranasal location (hazard ratio [HR], 4.61; 95% confidence interval [CI], 1.61-18.40; P =.030), positive lymph nodes (HR, 6.00; 95% CI, 1.30-27.7; P =.022), positive margins (HR, 4.32; 95% CI, 1.08-17.2; P =.039), bone invasion (HR, 3.27;95% CI, 1.05-10.1; P =.041), and lymphovascular invasion (HR, 3.82; CI, 1.03-14.2; P =.045). Three-year recurrence-free survival was 17.3%, and most of the recurrences were with distant disease. - Conclusions. HNMM is an infrequent disease with an aggressive behavior. Survival outcomes are related to location of the primary disease, regional spread, lymphovascular invasion, and bone invasion.