Abstract

Lichen simplex chronicus (LSC) is a common condition whose pathophysiology is partially known. The sensory innervation of the skin consists of a dermal plexus made up of myelinated and unmyelinated fibers. The epidermis only contains unmyelinated fibers, which indicate temperature, pain, and/or itching. Until now, the presence of small-fiber neuropathy in LSC had not been studied and its role in this disease was not known. Therefore, there was no documented therapy to treat this disease with the knowledge of its presence in it. A cohort of 33 patients with LSC who underwent study for the presence of fine fiber neuropathy and alteration in its function is presented.According to the results, a concept test of a novel therapy with lidocaine patches was carried out, proving to be effective.