Abstract

Obesity is a growing problem all around the world associated to multiple comorbidities and rising mortality. While efforts to comprehend physiological mechanisms involved in this disease have helped to better understand its prevalence and sequels, exact compromised mechanisms involved in metabolic changes are not fully understood. In this context, sympathetic nervous system hyperactivation counts on an important role on obesity, which could be related to the sequential development of type 2 diabetes mellitus and cardiovascular disease. In fact, commonly recommended strategies for obesity intervention, as diet and exercise aiming to weight loss, secondary associates to sympathetic inhibition. Thus, takes special relevance describe the exact mechanisms which link obesity and sympathetic nervous system activation. Researchers have proposed several theories to link these phenomena, until now, partially known.