6-bromoflavone, a high affinity ligand for the central benzodiazepine receptors is a member of a family of active flavonoids
Keywords: kinetics, acid, flavonoids, mouse, animals, maze, binding, learning, structure, mice, experiment, male, receptor, motor, agents, flavonoid, tissue, affinity, drug, molecular, article, variance, analysis, activity, benzodiazepine, controlled, animal, relation, labels, study, relationship, derivative, priority, of, flavone, bromination, intraperitoneal, administration, nonhuman, journal, tranquilizing, Anti-Anxiety, Flunitrazepam, gamma-Aminobutyric, Receptors,, GABA-A, Structure-Activity, Animalia
Abstract
6-Bromoflavone, obtained by bromination of flavanone, binds to central benzodiazepine receptors with a Ki = 70 nM and has a clear anxiolytic activity in mice, at 0.5 mg/kg, i.p. A survey of the structure/affinity relationship for those receptors in a series of natural and synthetic flavonoids is presented.
Más información
Título de la Revista: | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS |
Volumen: | 223 |
Número: | 2 |
Editorial: | ACADEMIC PRESS INC ELSEVIER SCIENCE |
Fecha de publicación: | 1996 |
Página de inicio: | 384 |
Página final: | 389 |
URL: | http://www.scopus.com/inward/record.url?eid=2-s2.0-0004396593&partnerID=q2rCbXpz |