Effects of benzodiazepine receptor ligands on isolated rat superior cervical ganglia neurons

Aguayo, L. G.; Cisternas C.; Tapia, J.C.; Pancetti F.C.

Keywords: acid, age, ligands, neurons, rat, membrane, animals, rats, cell, beta, ligand, diazepam, receptor, agents, newborn, methyl, electrophysiology, nerve, tissue, article, ester, concentration, benzodiazepine, superior, controlled, animal, factors, current, carboline, ethyl, study, 4, 8, 3, response, derivative, priority, nonhuman, journal, Anti-Anxiety, gamma-Aminobutyric, Receptors,, GABA-A, Rats,, Sprague-Dawley, aminobutyric, effect, cervical, Animals,, side, (3, 5, 6, trifluoromethylphenyl), 1,2,4, triazolo[4,3, b]pyridazine, azido, 5,6, dihydro, oxo, 4h, imidazo[1,5, a][1,4]benzodiazepine, carboxylic, flumazenil, ganglion, Pyridazines

Abstract

We studied the effects of diazepam, CL 218,872, Ro 15-1788, ?-CCM and Ro 15-4513 on the ?-aminobutyric acid-activated current in adult and newborn rat superior cervical ganglion neurons. Diazepam (10-1,000 nmol/l) potentiated the current in a concentration-dependent manner. CL 218,872 was less effective and weaker than diazepam. The other ligands reduced the amplitude of the current. These peripheral receptors might be involved in some of the side effects of benzodiazepines.

Más información

Título de la Revista: PHARMACOLOGY
Volumen: 52
Número: 6
Editorial: Karger
Fecha de publicación: 1996
Página de inicio: 371
Página final: 376
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-0029841391&partnerID=q2rCbXpz