Abstract

To determinate the effect of the early human development on the modulation of SS in the ERR, we studied the changes in the mean amplitude and mean latency of the maximal retinal response (MRR), background retinal response (BKD.16) and cone response at 30 Hz (30Hz.4) in function of SS, at differents ages. We registered full-field-electroretinogram to 23 healthy premature infants, adequate for gestational age, at 36, 40 and 57 postconceptional weeks old (PCA). All the infants were registered during a spontaneous nap, between 14 and 16 PM. The SS (quiet sleep:QS and active sleep: AS) were determined by the concordance of behavioral variables. Results: At 36 and 40 PCA, the in Can amplitude of MRR, BKD.16 and 30Hz.4, were significantly greater during AS than during QS (p<0.005). At 57 PCA, the mean amplitude were not different between SS for the MRR and Bkd.16, while the mean amplitude of 30 Hz 4 persisted higher during the AS. No differences were found in mean latencies. These results indicate that at 36 and 40 PCA, the SS modulate the amplitude of the studied responses, however that effect is lesser evident at 57 PCA. Conclusion: The modulator, effect of SS on the ERR changes throughout early human development (Grants: FONDECYT 1940467, 1930820; NIH HD 22380).