Testicular toxicity assesment of Andrographis paniculata dried extract in rats

burgos R.A.; Caballero E.E.; Sanchez N.S.; Schroeder R.A.; Hancke J.L.; Wikman G.K.

Keywords: chemistry, disorder, electron, rat, size, toxicity, animals, weight, cells, blood, rats, extract, plant, cell, histology, disease, ultrastructure, testis, microscopy, diseases, male, level, extracts, tissue, testosterone, leydig, drug, reproductive, pathology, article, testing, paniculata, organ, controlled, animal, andrographis, study, induced, administration, nonhuman, Rats,, Sprague-Dawley, Sprague, Dawley, chemically, effect, Plants,, Microscopy,, Medicinal, intragastric, Testicular

Abstract

The possible testicular toxicity of Andrographis paniculata, Nees (Acanthaceae) standardized dried extract was evaluated in male Sprague Dawley rats for 60 days. No testicular toxicity was found with the treatment of 20, 200 and 1000 mg/kg during 60 days as evaluated by reproductive organ weight, testicular histology, ultrastructural analysis of Leydig cells and testosterone levels after 60 days of treatment. It is concluded that Andrographis paniculata dried extract did not produce subchronic testicular toxicity effect in male rats.

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Título de la Revista: JOURNAL OF ETHNOPHARMACOLOGY
Volumen: 58
Número: 3
Editorial: ELSEVIER IRELAND LTD
Fecha de publicación: 1997
Página de inicio: 219
Página final: 224
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-0030609172&partnerID=q2rCbXpz