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Interleukin-1? does not increase synaptic inhibition in hippocampal CA3 pyramidal and dentate gyrus granule cells of the rat in vitro
Keywords: oxygen, neurons, inhibition, rat, density, membrane, animals, transmission, cells, brain, rats, cell, long, clamp, consumption, term, male, receptor, patch-clamp, vitro, cytology, nerve, hippocampus, potentiation, drug, article, interleukin-1, granule, techniques, animal, study, 1, interleukin, steady, priority, gyrus, in, nonhuman, journal, Rats,, Sprague-Dawley, Sprague, Dawley, effect, potential, patch, intracellular, pyramidal, Neural, Recording, 1beta, Synaptic, dentate
Abstract
Effects of interleukin-1? (bath-applied; 500 pM) on rat hippocampal CA3 pyramidal and dentate granule cells were studied using intracellular microelectrode recording in vitro. In both cell types membrane input resistance, resting membrane potential and action potential amplitude remained stable throughout. No change was seen in postsynaptic potentials in granule cells. After blocking excitatory synaptic transmission in CA3 pyramids interleukin-1? was found to consistently decrease synaptic inhibition by about 30%.
Más información
| Título de la Revista: | BRAIN RESEARCH |
| Volumen: | 768 |
| Número: | 1-2 |
| Editorial: | Elsevier |
| Fecha de publicación: | 1997 |
| Página de inicio: | 341 |
| Página final: | 344 |
| URL: | http://www.scopus.com/inward/record.url?eid=2-s2.0-0030613694&partnerID=q2rCbXpz |