Sodium nitroprusside blocks the cat carotid chemosensory inhibition induced by dopamine, but not that by hyperoxia

Iturriaga R.; Rey, S; Alcayaga J.

Keywords: stimulation, inhibition, enzyme, animals, transmission, arteries, blood, dopamine, pressure, experiment, hyperoxia, sodium, cat, methyl, chemoreceptors, nitroprusside, cyanide, inhibitors, article, ester, ventilation, cats, artificial, sinus, arterial, controlled, animal, sensory, study, priority, carotid, nonhuman, journal, Neural, n(g), nitroarginine, dopaminergic, NG-Nitroarginine


We studied the effects of the nitric oxide (NO) synthase inhibitor, N?- nitro-L-arginine methyl ester (L-NAME), and the NO donor, sodium nitroprusside (SNP) on cat chemosensory responses to intravenous injections of NaCN (0.1-100 ?g/kg) and dopamine (0.1-20 ?g/kg), and to hyperoxic ventilation (100% O2, 60-120 s). Cats were anesthetized with sodium pentobarbitone, paralyzed and artificially ventilated to prevent secondary ventilatory effects. The frequency of chemosensory discharges (f(x)) was recorded from one sectioned carotid sinus nerve. L-NAME (50 mg/kg i.v.) increased basal f(x) and slightly potentiated the responses to NaCN and dopamine. SNP (1-2 mg/kg i.v.) increased basal f(x), but reduced the NaCN- induced increases of f(x) over baseline and the transient f(x) inhibitions induced by dopamine, but not those produced by hyperoxia. Present results indicate that besides the known inhibitory effect of NO on chemosensory responses to low PO2, NO also blocks the chemosensory response to dopamine, leaving hyperoxic responses largely unchanged.

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Título de la Revista: BRAIN RESEARCH
Volumen: 799
Número: 1
Editorial: Elsevier
Fecha de publicación: 1998
Página de inicio: 26
Página final: 34