Estrés oxidativo e inflamación en insuficiencia cardiaca: Mecanismos de daño y alternativas terapéuticas

Miranda H, Rodrigo; Castro G, Pablo; Verdejo P, Hugo; Chiong, Mario; Diaz-Araya, Guillermo; Mellado, Rosemarie; Rojas, Diego; Concepción, Roberto; Lavandera, Sergio

Abstract

"Despite advances in treatment, chronic heart failure still is associated with a poor prognosis and remains a leading cause of cardiovascular death. Cumulating evidence suggests that imbalances in redox state lead to a higher generation of reactive oxygen species. This phenomenon, along with pro-inflammatory cytokine activation and extra cellular matrix alterations with reactive fibrosis, play an important role in the pathogenesis and progression of heart failure, through the development of endothelial and myocardial dysfunction. The understanding of the underlying phenomena and the metabolic pathways involved will allow further development of therapies aiming to change the natural history of heart failure (Rev M

Más información

Título según SCIELO: Estrés oxidativo e inflamación en insuficiencia cardiaca: Mecanismos de daño y alternativas terapéuticas
Título de la Revista: REVISTA MEDICA DE CHILE
Volumen: 135
Número: 8
Editorial: SOC MEDICA SANTIAGO
Fecha de publicación: 2007
Página de inicio: 1056
Página final: 1063
Idioma: es
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007000800015&lng=en&nrm=iso&tlng=en
DOI:

10.4067/S0034-98872007000800015

Notas: SCIELO