Fisiopatología de la hipertensión asociada al síndrome de apnea obstructiva del sueño: Evidencia de estudios clínicos y modelos animales de hipoxia crónica intermitente

Rey, Sergio; Valdés, Gloria; Iturriaga, Rodrigo

Keywords: hypertension, sleep apnea, obstructive, anoxemia

Abstract

There is a well established relationship between the obstructive sleep apnea syndrome and hypertension. Current evidence suggests that the increase in arterial pressure is secondary to an enhanced sympathetic tone through peripheral chemoreflexes triggered by intermittent hypoxic stimulation of the carotid bodies. Chronic intermittent hypoxia would activate renal and systemic vasoactive systems through potentiated hypoxic chemoreflexes. These early changes in autonomic tone can be detected through cardiovascular variability and baroreflex sensitivity analysis. Both are relatively simple and noninvasive techniques. The multiplicity of pathogenic mechanisms in obstructive sleep apnea-associated hypertension emphasizes the need of increasing diagnostic sensitivity to detect and correct this common condition, which significantly increases cardiovascular risk

Más información

Título según SCIELO: Fisiopatolog�a de la hipertensi�n asociada al s�ndrome de apnea obstructiva del sue�o: Evidencia de estudios cl�nicos y modelos animales de hipoxia cr�nica intermitente
Título de la Revista: REVISTA MEDICA DE CHILE
Volumen: 135
Número: 10
Editorial: SOC MEDICA SANTIAGO
Fecha de publicación: 2007
Página de inicio: 1333
Página final: 1342
Idioma: es
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007001000016&lng=en&nrm=iso&tlng=en
DOI:

10.4067/S0034-98872007001000016

Notas: SCIELO