Rol del riñón en la hipertensión sal-sensible

Ardiles, Leopoldo; Mezzano, Sergio

Keywords: kidney diseases, natriuresis, hypertension, renal


An important proportion of patients with essential hypertension are salt sensitive, defined as those who experience signifcant blood pressure changes according to the amount of salt intake. They have a disturbance in the pressure induced natriuresis mechanism and their kidneys have functional and morphological alterations con-sistent with an acquired tubulointerstitial alteration, afferent arteriole damage and alteration of peritubular capillaries. All these alterations lead to disturbances in sodium load excretion under normal pressures. There is also an associated activation of kidney vasoconstrictor/salt retaining systems and a reduction in the vasodilator/ salt eliminating mechanisms. These alterations, that originate early in life, generate a new blood pressure level, that corrects natriuresis at the expense of a sustained hypertension.

Más información

Título según SCIELO: Rol del riñón en la hipertensión sal-sensible
Título de la Revista: REVISTA MEDICA DE CHILE
Volumen: 138
Número: 7
Editorial: Sociedad Médica de Santiago
Fecha de publicación: 2010
Página de inicio: 862
Página final: 867
Idioma: es