Caloric restriction and aging stem cells: The stick and the carrot?

Mazzoccoli, G; Tevy MF; Borghesan, M; Delle Vergini, MR; Vinciguerra, M


Adult tissue stem cells have the ability to adjust to environmental changes and affect also the proliferation of neighboring cells, with important consequences on tissue maintenance and regeneration. Stem cell renewal and proliferation is strongly regulated during aging of the organism. Caloric restriction is the most powerful anti-aging strategy conserved throughout evolution in the animal kingdom. Recent studies relate the properties of caloric restriction to its ability in reprogramming stem-like cell states and in prolonging the capacity of stem cells to self-renew, proliferate, differentiate, and replace cells in several adult tissues. However this general paradigm presents with exceptions. The scope of this review is to highlight how caloric restriction impacts on diverse stem cell compartments and, by doing so, might differentially delay aging in the tissues of lower and higher organisms. (C) 2013 Elsevier Inc. All rights reserved.

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Título según WOS: Caloric restriction and aging stem cells: The stick and the carrot?
Volumen: 50
Editorial: Pergamon Press
Fecha de publicación: 2014
Página de inicio: 137
Página final: 148
Idioma: English


Notas: ISI