Levels of inflammatory cytokines and plasma cortisol in respiratory syncytial virus bronchiolitis

Diaz, PV; Gaggero, AA; Pinto, RA; Mamani, R; UASAPUD PA; Bono, MR.

Abstract

Background: An increased inflammatory innate response may play a role in pathogenesis of respiratory syncytial virus (RSV) infection. Aim: To quantify pro-inflammatory cytokines (IL-6-IL-8, IL-1-beta and TNF-alpha) in nasopharyngeal aspirate (NPA) and plasma, and plasma cortisol in previously healthy infants with RSV bronchiolitis. Patients and Methods: We studied 49 infants aged less than one year of age with RSV bronchiolitis and 25 healthy controls. Severity was defined using a previously described modified score. We quantified interleukins in NPA and plasma by flow cytometry and plasma cortisol by radioimmunoanalysis. Results: Among patients with RSV bronchiolitis, 25 were classified as severe and 24 as moderate or mild. Significantly higher levels of IL-6 and IL-8 in NPA and plasma and IL-1 beta in NPA were found in children classified as severe, when compared to those with moderate or mild disease and controls. There was a positive correlation between IL-6 and cortisol in plasma (r = 0,55; p < 0,0001) and both were correlated with the severity of the disease. Conclusions: RSV bronchiolitis severity was associated with higher levels of inflammatory interleukins and plasma cortisol.

Más información

Título según WOS: Levels of inflammatory cytokines and plasma cortisol in respiratory syncytial virus bronchiolitis
Título de la Revista: Revista Médica de Chile
Volumen: 141
Número: 5
Editorial: Sociedad Médica de Santiago
Fecha de publicación: 2013
Página de inicio: 574
Página final: 581
Idioma: Spanish
Notas: ISI