Modeling acclimatization by hybrid systems: Condition changes alter biological system behavior models

Assar, R; Montecino MA; Maass A.; Sherman, DJ

Abstract

In order to describe the dynamic behavior of a complex biological system, it is useful to combine models integrating processes at different levels and with temporal dependencies. Such combinations are necessary for modeling acclimatization, a phenomenon where changes in environmental conditions can induce drastic changes in the behavior of a biological system. In this article we formalize the use of hybrid systems as a tool to model this kind of biological behavior. A modeling scheme called strong switches is proposed. It allows one to take into account both minor adjustments to the coefficients of a continuous model, and, more interestingly, large-scale changes to the structure of the model. We illustrate the proposed methodology with two applications: acclimatization in wine fermentation kinetics, and acclimatization of osteo-adipo differentiation system linking stimulus signals to bone mass. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

Más información

Título según WOS: Modeling acclimatization by hybrid systems: Condition changes alter biological system behavior models
Título según SCOPUS: Modeling acclimatization by hybrid systems: Condition changes alter biological system behavior models
Título de la Revista: BIOSYSTEMS
Volumen: 121
Editorial: Sciencedirect
Fecha de publicación: 2014
Página de inicio: 43
Página final: 53
Idioma: English
DOI:

10.1016/j.biosystems.2014.05.007

Notas: ISI, SCOPUS