Clostridium difficile spores and its relevance in the persistence and transmission of the infection

Barra-Carrasco, J; Hernandez-Rocha, C; Ibáñez P.; Guzman-Duran, AM; Alvarez-Lobos, M; Paredes Sabja D

Keywords: spores, clostridium difficile, nosocomial diarrhea

Abstract

C. difficile is an anaerobic spore former pathogen and the most important etiologic agent of nosocomial and community acquired antibiotics associated diarrheas. C. difficile infections (CDI) are responsible for an elevated rate of morbidity in developed and developing countries. Although the major virulence factors responsible for clinical symptoms of CDI are the two toxins TcdA and TcdB, C. difficile spores are the main Vehicle of infection, persistence and transmission of CDI. Recent work has unrevealed unique properties of C. difficile spores that Make them remarkable morphotypes of persistence and transmission in the host, including their resistance to antibiotics, the host immune response and disinfectants. The present review summarizes relevant aspects of C. difficile spore biology that have major implications from a clinical and medical perspective.

Más información

Título según WOS: Clostridium difficile spores and its relevance in the persistence and transmission of the infection
Título de la Revista: Revista Chilena de Infectologia
Volumen: 31
Número: 6
Editorial: Sociedad Chilena de Infectología
Fecha de publicación: 2014
Página de inicio: 694
Página final: 703
Idioma: Spanish
Notas: ISI