Rho GTPases at the crossroad of signaling networks in mammals: impact of Rho-GTPases on microtubule organization and dynamics

Wojnacki J1, Quassollo G, Marzolo MP, Cáceres A

Keywords: migration, stabilization, microtubules, polarity, small gtpases, actin filaments, protrusion


Microtubule (MT) organization and dynamics downstream of external cues is crucial for maintaining cellular architecture and the generation of cell asymmetries. In interphase cells RhoA, Rac, and Cdc42, conspicuous members of the family of small Rho GTPases, have major roles in modulating MT stability, and hence polarized cell behaviors. However, MTs are not mere targets of Rho GTPases, but also serve as signaling platforms coupling MT dynamics to Rho GTPase activation in a variety of cellular conditions. In this article, we review some of the key studies describing the reciprocal relationship between small Rho-GTPases and MTs during migration and polarization.

Más información

Título de la Revista: Small GTPases
Volumen: 5
Editorial: Landes Bioscience
Fecha de publicación: 2014
Página de inicio: e28430
Idioma: English