Modulation of rat liver cytochrome P450 activity by prolonged red wine consumption

Orellana M.; Varela, N; Guajardo, V; Araya J.; Rodrigo R.

Abstract

Cytochrome P450-dependent oxidation of lauric acid, p-nitrophenol and ethanol by liver microsomal fractions were studied in control rats and in animals given either ethanol, red wine, or alcohol-free red wine for 10 weeks. Ethanol increased the total cytochrome P450 and the isoenzyme 2E1 content, as well as the p-nitrophenol hydroxylation and ethanol oxidation. These effects of ethanol treatment were attenuated by red wine administration. Red wine increased the total antioxidant capacity of plasma, whereas the alcohol-free red wine decreased the cytochrome P450 content and decreased the oxidation of lauric acid, p-nitrophenol and ethanol to values lower than control. It is concluded that red wine administration attenuates the ethanol-induced enhancement in liver microsomal parameters dependent on cytochrome P450 2E1 activity, an affect that seems to be accomplished by the non-alcoholic constituents of red wine known to have antioxidant properties. © 2002 Elsevier Science Inc. All rights reserved.

Más información

Título según WOS: Modulation of rat liver cytochrome P450 activity by prolonged red wine consumption
Título según SCOPUS: Modulation of rat liver cytochrome P450 activity by prolonged red wine consumption
Título de la Revista: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY PHARMACOLOGY
Volumen: 131
Número: 2
Editorial: Elsevier Science Inc.
Fecha de publicación: 2002
Página de inicio: 161
Página final: 166
Idioma: English
URL: http://linkinghub.elsevier.com/retrieve/pii/S1532045601002927
DOI:

10.1016/S1532-0456(01)00292-7

Notas: ISI, SCOPUS