New Insights into Peptide-Silver Nanoparticle Interaction: Deciphering the Role of Cysteine and Lysine in the Peptide Sequence

Poblete, Horacio; Agarwal, Anirudh; Thomas, Suma S.; Bohne, Cornelia; Ravichandran, Ranjithkumar; Phospase, Jaywant; Comer, Jeffrey; Alarcon, Emilio I.


We studied the interaction of four new pentapeptides with spherical silver nanoparticles. Our findings indicate that the combination of the thiol in Cys and amines in Lys/Arg residues is critical to providing stable protection for the silver surface. Molecular simulation reveals the atomic scale interactions that underlie the observed stabilizing effect of these peptides, while yielding qualitative agreement with experiment for ranking the affinity of the four pentapeptides for the silver surface.

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Título según WOS: ID WOS:000368321700031 Not found in local WOS DB
Título de la Revista: LANGMUIR
Volumen: 32
Número: 1
Fecha de publicación: 2016
Página de inicio: 265
Página final: 273


Notas: ISI