Synthesis and Anti-SaprolegniaActivity of New 2',4'-Dihydroxydihydrochalcone Derivatives

Werner, Enrique; Montenegro, Ivan; Said, Bastian; Godoy, Patricio; Besoain, Ximena; Caro, Nelson; Madrid, Alejandro

Abstract

In the present study, seven 2',4'-dihydroxydihydrochalcone derivatives (compounds3-9) were synthesized and their capacity as anti-Saprolegniaagents were evaluated againstSaprolegnia parasitica,S. australis,S. diclina. Derivative9showed the best activity against the different strains, with minimum inhibitory concentration (MIC) and minimum oomyceticidal concentration (MOC) values between 100-175 mu g/mL and 100-200 mu g/mL, respectively, compared with bronopol and fluconazole as positive controls. In addition, compound9caused damage and disintegration cell membrane of allSaprolegniastrains over the action of commercial controls.

Más información

Título según WOS: ID WOS:000552458100001 Not found in local WOS DB
Título de la Revista: ANTIBIOTICS-BASEL
Volumen: 9
Número: 6
Editorial: MDPI
Fecha de publicación: 2020
DOI:

10.3390/antibiotics9060317

Notas: ISI