Hexose Transporters in Cancer: From Multifunctionality to Diagnosis and Therapy

Echeverria, Carolina; Nualart, Francisco; Ferrada, Luciano; Smith, Gary J.; Godoy, Alejandro S.

Abstract

Cancer cells increase their metabolic activity by enhancing glucose uptake through overexpression of hexose transporters (Gluts). Gluts also have the capacity to transport other molecules besides glucose, including fructose, mannose, and dehydroascorbic acid (DHA), the oxidized form of vitamin C. The majority of research studies in this field have focused on the role of glucose transport and metabolism in cancer, leaving a substantial gap in our knowledge of the contribution of other hexoses and DHA in cancer biology. Here, we summarize the most recent advances in understanding the role that the multifunctional transport capacity of Gluts plays in biological and clinical aspects of cancer, and how these characteristics can be exploited in the search for novel diagnostic and therapeutic strategies.

Más información

Título según WOS: ID WOS:000627403000004 Not found in local WOS DB
Título de la Revista: TRENDS IN ENDOCRINOLOGY AND METABOLISM
Volumen: 32
Número: 4
Editorial: Cell Press
Fecha de publicación: 2021
Página de inicio: 198
Página final: 211
DOI:

10.1016/j.tem.2020.12.006

Notas: ISI