Multiplicity of protein interactions and functions of the voltage-gated calcium channel beta-subunit
For a long time the auxiliary Î²-subunit of voltage-gated calcium channels was thought to be engaged exclusively in the regulation of calcium channel function, including gating, intracellular trafficking, assembly and membrane expression. The Î²-subunit belongs to the membrane-associated guanylate kinase class of scaffolding proteins (MAGUK) that comprises a series of protein interaction motifs. Two such domains, a Src homology 3 and a guanylate kinase domain are present in the Î²-subunit. Recently, it was shown that this subunit interacts with a variety of proteins and regulates diverse cellular processes ranging from gene expression to hormone secretion and endocytosis. In light of these new findings, the Î²-subunit deserves to be promoted to the category of multifunctional regulatory protein. Some of these new functions support a tighter regulation of calcium influx through voltage-gated calcium channels and others apparently serve channel unrelated processes. Here we discuss a variety of protein-protein interactions held by the Î²-subunit of voltage-gated calcium channels and their functional consequences. Certainly the identification of additional binding partners and effector pathways will help to understand how the different Î²-subunit-mediated processes are interwoven. Â© 2007 Elsevier Ltd. All rights reserved.
|Título según WOS:||Multiplicity of protein interactions and functions of the voltage-gated calcium channel beta-subunit|
|Título según SCOPUS:||Multiplicity of protein interactions and functions of the voltage-gated calcium channel ß-subunit|
|Título de la Revista:||CELL CALCIUM|
|Editorial:||ELSEVIER SCI LTD|
|Fecha de publicación:||2007|
|Página de inicio:||389|