Frailty Index as a Predictor of Mortality in Middle-Aged and Older People: A Prospective Analysis of Chilean Adults.

1. Diaz-Toro F, Nazar G, Troncoso C, Concha-Cisternas Y, Leiva-Ordoñez AM, Martinez-Sanguinetti MA, Parra-Soto S, Lasserre-Laso N, Cigarroa I, Mardones L, Vásquez-Gómez J, Petermann-Rocha F, Diaz-Martinez X, and Celis-Morales C

Keywords: chile, mortality, middle-aged, frailty

Abstract

Abstract: We aimed to investigate the association between frailty status and all-cause mortality in middle-aged and older people. We included 2661 individuals aged  35 from the Chilean National Health Survey 2009–2010. Mortality was determined through linkage with the Chilean Civil Registry and Identification. A 36-item frailty index (FI) was used to assess the frailty status. Associations between frailty status and all-cause mortality were assessed using Kaplan–Meier and Cox proportional hazard models adjusted for sociodemographic and lifestyle factors. A non-linear association was investigated using penalized cubic splines fitted in the Cox models. During an 8.9 median follow-up (interquartile range of 8.6–9.0), 308 individuals died (11.5%). Lower survival rates were observed in frail individuals compared to pre-frail and robust people (log-rank < 0.001). Compared with robust individuals, frail people had a higher mortality risk (HR: 2.35 [95% CI: 1.57 to 3.51]). Frail middle-aged individuals had a higher risk of dying independently of major risk factors.

Más información

Título de la Revista: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
Volumen: 20
Editorial: MDPI
Fecha de publicación: 2023
Idioma: English