Modulatory effects of histamine on cat carotid body chemoreception

Del Rio R.; Moya, EA; Koenig, CS; Fujiwara, K; Alcayaga J.; Iturriaga R.

Abstract

Histamine has been proposed to be an excitatory transmitter between the carotid body (CB) chemoreceptor (glomus) cells and petrosal ganglion (PG) neurons. The histamine biosynthetic pathway, its storage and release, as well as the presence of histamine H1, H2 and H3 receptors have been found in the CB. However, there is only indirect evidence showing the presence of histamine in glomus cells, or weather its application produces chemosensory excitation. Thus, we studied the histamine immunocytochemical localization in the cat CB, and the effects of histamine, and H1, H2 and H3 receptor blockers on carotid sinus nerve (CSN) discharge, using CB and PG preparations in vitro. We found histamine immunoreactivity in dense-cored vesicles of glomus cells. Histamine induced dose-dependent increases in CSN discharge in the CB, but not in the PG. The H1-antagonist pyrilamine reduced the CB responses induced by histamine, the H2-antagonists cimetidine and ranitidine had no effect, while the H3-antagonist thioperamide enhanced histamine-induced responses. Present data suggests that histamine plays an excitatory modulatory role in the generation of cat CB chemosensory activity. © 2008 Elsevier B.V. All rights reserved.

Más información

Título según WOS: Modulatory effects of histamine on cat carotid body chemoreception
Título según SCOPUS: Modulatory effects of histamine on cat carotid body chemoreception
Título de la Revista: RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
Volumen: 164
Número: 3
Editorial: Elsevier
Fecha de publicación: 2008
Página de inicio: 401
Página final: 410
Idioma: English
URL: http://linkinghub.elsevier.com/retrieve/pii/S1569904808002413
DOI:

10.1016/j.resp.2008.09.005

Notas: ISI, SCOPUS