Frailty Index as a Predictor of Mortality in Middle-Aged and Older People: A Prospective Analysis of Chilean Adults

Diaz-Toro, Felipe; Nazar, Gabriela; Troncoso, Claudia; Concha-Cisternas, Yeny; Leiva-Ordonez, Ana Maria; Martinez-Sanguinetti, Maria Adela; Parra-Soto, Solange; Lasserre-Laso, Nicole; Cigarroa, Igor; Mardones, Lorena; Vasquez-Gomez, Jaime; Petermann-Rocha, Fanny; Diaz-Martinez, Ximena; Celis-Morales, Carlos; ELHOC Res Consortium

Abstract

We aimed to investigate the association between frailty status and all-cause mortality in middle-aged and older people. We included 2661 individuals aged >= 35 from the Chilean National Health Survey 2009-2010. Mortality was determined through linkage with the Chilean Civil Registry and Identification. A 36-item frailty index (FI) was used to assess the frailty status. Associations between frailty status and all-cause mortality were assessed using Kaplan-Meier and Cox proportional hazard models adjusted for sociodemographic and lifestyle factors. A non-linear association was investigated using penalized cubic splines fitted in the Cox models. During an 8.9 median follow-up (interquartile range of 8.6-9.0), 308 individuals died (11.5%). Lower survival rates were observed in frail individuals compared to pre-frail and robust people (log-rank 0.001). Compared with robust individuals, frail people had a higher mortality risk (HR: 2.35 [95% CI: 1.57 to 3.51]). Frail middle-aged individuals had a higher risk of dying independently of major risk factors.

Más información

Título según WOS: ID WOS:000917684000001 Not found in local WOS DB
Título de la Revista: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
Volumen: 20
Número: 2
Editorial: MDPI
Fecha de publicación: 2023
DOI:

10.3390/ijerph20021195

Notas: ISI