Title: Unvealing the functional role, signaling and biomarker utilityof KLK4 and KLK12 in breast cancer

Ehrenfeld, Pamela; Figueroa, Carlos Dario; Sanchez, Fabian; Rojas, Alejandro; Torres - Farfán, Claudia

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Fecha de publicación: 2020
Objetivos: To determine if KLK4 and KLK12 levels are increased in the sera of breast cancer patients; To determine the effect of KLK4 on adhesion, EMT, migration and invasion of breast cancer cells in vitro and breast cancer metastasis in vivo, To determine the effect of KLK12 on breast cancer cells to prod
Programa: FONDECYT
Año de Inicio/Término: 2020-2024
Financiamiento/Sponsor: CONICYT


Notas: We strongly believe that our study will contribute to a better understanding of the functional role of KLK 4 and KLK12 in breast cancer, if the proposed mechanisms are validated, the use of specific inhibitors for KLK4 or KLK12 or antagonists to their PARs partners should be considerer