Dosage matters: Uncovering the optimal duration of pain neuroscience education to improve psychosocial variables in chronic musculoskeletal pain. A systematic review and meta-analysis with moderator analysis

Salazar-Mendez, Joaquin; Nunez-Cortes, Rodrigo; Suso-Marti, Luis; Ribeiro, Ivana Leao; Garrido-Castillo, Maria; Gacitua, Jose; Mendez-Rebolledo, Guillermo; Cruz-Montecinos, Carlos; Lopez-Bueno, Ruben; Calatayud, Joaquin

Abstract

The aim was to examine the moderator effect of duration of PNE (total minutes) on changes in psychosocial variables after treatment in people with chronic musculoskeletal pain. PubMed/MEDLINE, Embase, Web of Science, Scopus and CINHAL databases were systematically searched from inception to 6 February 2023. A mixed-effects meta-regression was performed to determine the moderator effect of PNE duration. Twenty-three studies involving 2352 patients were included. Meta-analysis revealed a statistically significant effect in favour of PNE on pain neurophysiology knowledge, anxiety symptoms, catastrophizing and kinesi-ophobia. The total duration of PNE ranged from 40 to 720 min. A linear relationship was observed between longer duration of PNE (total minutes) and changes of psychosocial variables. In addition, a dose of 100, 200 and 400 min of PNE was estimated to exceed the minimum clinically important difference described in the literature for kinesiophobia (mean difference = -8.53 points), anxiety symptoms (mean difference = -1.88 points) and catastrophizing (mean difference = -7.17 points). Clinicians should provide a more tailored PNE to address psychosocial variables.

Más información

Título según WOS: ID WOS:001066028100001 Not found in local WOS DB
Título de la Revista: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
Volumen: 153
Editorial: PERGAMON-ELSEVIER SCIENCE LTD
Fecha de publicación: 2023
DOI:

10.1016/j.neubiorev.2023.105328

Notas: ISI