The effects of nasal desmopressin in the management of polyuria in Parkinson's disease. Report of 3 clinical cases Evaluacion de los efectos de la desmopresina intranasal para el manejo de casos con poliaquiuria en la Enfermedad de Parkinson. Presentacion de tres casos clinicos

Chana, P; Ilzauspe J.M.; Barrientos, N.

Keywords: acetate, disease, trial, levodopa, efficacy, human, male, aged, tolerability, adult, dose, female, drug, article, inhaler, intranasal, clinical, nose, spray, parkinson, desmopressin, administration, case, report, metered, nocturia, polyuria


Patients with Parkinson's disease (PD) are known to experience autonomic nervous system dysfunction. Including a wide variety of problems, as urinary urgency, frequency and nocturnal polyuria. The purpose of the present study was to assess the efficacy of desmopressin in 3 patients with PD with significant nocturia. They were first asked and self-questionnaire to establish a baseline and control to 4 weeks of number of nocturnal voids. The patients were prescribed the metered dose nasal spray form of desmopressine acetate and instructed to administer one metered-dose spray (10 ?g) into one nostril at bedtime for 1 week, the dose was increased to one in each nostril at bedtime (20 ?g) at second week. 3 patients participated, their ages 67, 59 and 81 years, with Hoehn and Yahr stages of 4. All patients were on levodopa preparations. Two patients completed the trial, they showed a decrease in the number of nocturnal voids. One patient failed to complete the drug trial for impaired of PD symptoms. Desmopressine was tolerated well.

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Título de la Revista: Revista Chilena de Neuro-Psiquiatria
Volumen: 35
Número: 1
Editorial: Sociedad Chilena de Neurologia psiquiatria y Neurocirugia
Fecha de publicación: 1997
Página de inicio: 37
Página final: 41