Cat carotid body chemosensory responses to non-hypoxic stimuli are inhibited by sodium nitroprusside in situ and in vitro

Alcayaga J.; ramirez, j; Readi R.; Quezada C.; Salinas P.; Iturriaga R.

Keywords: animals, chemoreceptor, hypoxia, experiment, transduction, male, nicotine, oxide, sodium, cat, chemoreceptors, nerve, nitroprusside, cyanide, tissue, body, female, signal, drug, article, anoxia, dose-response, cats, donor, sinus, controlled, chemosensitivity, animal, study, priority, carotid, nonhuman, journal, Relationship,, nitric, Ganglionic, Stimulants


We studied the effects of sodium nitroprusside, a nitric oxide donor, on the chemosensory responses to cyanide and nicotine in the cat carotid body. In situ, sodium nitroprusside infusion reduced the cyanide-evoked responses in a dose-dependent manner. In vitro, Tyrode containing nitroprusside reversibly reduced the cyanide- (by 59%) and nicotine-induced (by 45%) chemosensory responses. The present results suggest that chemosensory responses induced by cyanide and nicotine are reduced by increased nitric oxide content, similarly to the hypoxic chemosensory responses.

Más información

Título de la Revista: BRAIN RESEARCH
Volumen: 767
Número: 2
Editorial: Elsevier
Fecha de publicación: 1997
Página de inicio: 384
Página final: 387