Effects of antihypertensive treatment on cardiac IGF-1 during prevention of ventricular hypertrophy in the rat

Jalil J.E.; Ebensperger, R; Meléndez J.; Acevedo, E; Sapag-Hagar, M; Gonzalez-Jara, F; Galvez A.; Perez-Montes V.; Lavandero S.

Keywords: model, growth, rat, hormone, heart, therapy, animals, hypertension, blood, rats, protein, hypertrophy, pressure, pathogenesis, enalapril, mass, experiment, male, agents, losartan, level, agent, drug, radioimmunoassay, article, myocardium, factor, propranolol, oral, arterial, controlled, ventricle, animal, c, study, left, administration, nonhuman, Animalia, Rats,, Sprague-Dawley, effect, I, antihypertensive, Hypertrophy,, Ventricular, somatomedin, Insulin-Like, methyldopa


There is some evidence that cardiac rather than circulating insulin- like growth factor-1 (IGF-1) levels contribute to the development of renovascular hypertensive left ventricular hypertrophy (LVH), remaining unknown the effects of antihypertensive drugs on IGF-1 levels. We have assessed here the preventive effects of enalapril, losartan, propanolol and ?-methyldopa on left ventricle (LV) and circulating IGF-1 levels in a rat model of hypertension and LVH (Goldblatt, GB). Our results show that relative LV mass and the LV content of IGF-1 were significantly lower with all antihypertensive drags in GB rats (p<0.001). Serum concentrations of IGF-1 were lower in GB rats treated with enalapril, ?-methyldopa and propanolol (p<0.01), but not in those treated with losartan. These results support the hypothesis that local rather than seric IGF-1 contributes to the development of left ventricular hypertrophy induced by pressure overload in the rat.

Más información

Título de la Revista: LIFE SCIENCES
Volumen: 64
Número: 18
Fecha de publicación: 1999
Página de inicio: 1603
Página final: 1612
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-0033605841&partnerID=q2rCbXpz