Human metapneumovirus as hospitalization cause in children under 3 years old with acute respiratory infections during 2004 Metapneumovirus humano como causa de hospitalización en niños bajo 3 años de edad, con infección respiratoria aguda, durante el año 2004

Prado Sanhueza M.A.; Perret P C.; Montecinos P L.; Veloz B. A.; le Corre P. N.; Habash A. L.; Potin S M; Abarca V K.; Ferrés G M

Keywords: isolation, chile, purification, infections, infection, transcription, disease, chain, virus, humans, human, male, genetics, polymerase, newborn, female, infant, article, child, tract, respiratory, acute, hospitalization, preschool, reverse, metapneumovirus, studies, study, Reaction, Child,, and, prospective, virology, Infant,, Paramyxoviridae, Transcriptase


Human metapneumovirus was detected in 15 of 123 children (12%) younger than 3 years of age hospitalized for treatment of acute respiratory infection between July and November 2004. The virus was detected by RT-PCR directly from nasopharyngeal swabs and/or from supernatants after cell culture. Children infected with hMPV were mostly younger than one year of age (67%), all presenting with fever and cough. The main cause for hospitalization was the need for oxygen therapy (73%). Four hMPV positive children had an identifiable co-morbid condition but had a similar clinical evolution when compared to previously healthy infants. Chest radiography showed an increase in interstitial infiltrates with focal consolidation in 6 children. Obstructive bronchial syndrome and bronchiolitis, with or without pneumonia, were the most frequent diagnosis associated with hMPV positivity. A rapid and sensitive diagnostic method is required to improve diagnosis and treatment of these patients. © 2007 Sociedad Chilena de Infectología.

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Título de la Revista: Revista Chilena de Infectologia
Volumen: 24
Número: 1
Editorial: Sociedad Chilena de Infectología
Fecha de publicación: 2007
Página de inicio: 19
Página final: 26