Effects of interleukin-1? on spinal cord nociceptive transmission in intact and propentofylline-treated rats

Arriagada, O.; Constandil, L; Hernandez A.; Barra, R; Soto-Moyano, R; Laurido C.

Keywords: disorder, rat, fiber, animals, cytokine, transmission, rats, cell, fibers, physiology, experiment, pain, receptor, agents, cord, methodology, pathophysiology, nerve, measurement, agent, dose, nociception, drug, reflex, article, dose-response, spinal, glia, neurotransmission, assessment, nociceptors, xanthines, controlled, animal, propentofylline, c, study, response, interleukin, derivative, induced, intraperitoneal, administration, nonhuman, Rats,, Sprague-Dawley, Sprague, Dawley, chemically, effect, Relationship,, Injections,, electrostimulation, nociceptive, xanthine, 1beta, Synaptic, horn, dorsal, Neuroprotective, Interleukin-1beta


To investigate the contribution of glial cells in the spinal cord nociceptive transmission, the effect of intrathecally administered interleukin-1? (IL-1?) was studied in rats treated with the glial cell inactivator propentofylline and submitted to a C-fiber-mediated reflex paradigm evoked by single and repetitive (wind-up) electric stimulation. Intrathecal IL-1? did not modify the C reflex integrated activity in either group of animals, while producing increased wind-up in intact and decreased wind-up in propentofylline pre-treated rats. Results suggest that the excitatory effect of IL-1? on spinal wind-up activity in healthy rats is produced by a glial mediator, whereas the inhibitory effect resulted from a direct effect of the cytokine on dorsal horn neurons. Copyright © 2007 Informa Healthcare.

Más información

Volumen: 117
Número: 5
Editorial: Informa Healthcare
Fecha de publicación: 2007
Página de inicio: 617
Página final: 625
URL: http://www.scopus.com/inward/record.url?eid=2-s2.0-34247600646&partnerID=q2rCbXpz