Effects of interleukin-1? on spinal cord nociceptive transmission in intact and propentofylline-treated rats
Keywords: disorder, rat, fiber, animals, cytokine, transmission, rats, cell, fibers, physiology, experiment, pain, receptor, agents, cord, methodology, pathophysiology, nerve, measurement, agent, dose, nociception, drug, reflex, article, dose-response, spinal, glia, neurotransmission, assessment, nociceptors, xanthines, controlled, animal, propentofylline, c, study, response, interleukin, derivative, induced, intraperitoneal, administration, nonhuman, Rats,, Sprague-Dawley, Sprague, Dawley, chemically, effect, Relationship,, Injections,, electrostimulation, nociceptive, xanthine, 1beta, Synaptic, horn, dorsal, Neuroprotective, Interleukin-1beta
To investigate the contribution of glial cells in the spinal cord nociceptive transmission, the effect of intrathecally administered interleukin-1? (IL-1?) was studied in rats treated with the glial cell inactivator propentofylline and submitted to a C-fiber-mediated reflex paradigm evoked by single and repetitive (wind-up) electric stimulation. Intrathecal IL-1? did not modify the C reflex integrated activity in either group of animals, while producing increased wind-up in intact and decreased wind-up in propentofylline pre-treated rats. Results suggest that the excitatory effect of IL-1? on spinal wind-up activity in healthy rats is produced by a glial mediator, whereas the inhibitory effect resulted from a direct effect of the cytokine on dorsal horn neurons. Copyright © 2007 Informa Healthcare.
|Título de la Revista:||INTERNATIONAL JOURNAL OF NEUROSCIENCE|
|Fecha de publicación:||2007|
|Página de inicio:||617|