Inflammation and endothelial dysfunction in patients with chronic heart failure Inflamación y disfunción endotelial en pacientes con insuficiencia cardiaca crónica

greig d.; Castro P. ; Gabrielli, L; Miranda, R.; Verdejo H.; Godoy, I.; Alcaino H; Bustos C.; Chiong M.; Mellado R.; Garcia, L.; Salas, D.; Vivar, R; Diaz-Araya, G; Vukasovic J.L.; et. al.

Keywords: endothelium, heart, inflammation, blood, protein, disease, markers, alpha, physiology, metabolism, tumor, humans, human, male, vasodilation, failure, aged, pathophysiology, adult, female, necrosis, factor-alpha, vasodilatation, drug, interleukin-6, article, marker, factor, mediators, young, chronic, vascular, c, interleukin, middle, effect, biological, and, Reactive, Aged,, 80, over, Endothelium,, 6, C-Reactive, autacoid


Background: In chronic heart failure (CHF), endothelial dysfunction (ED) is a consequence of an imbalance of vascular tone regulating substances. The relationship between ED and inflammation has not been fully investigated. Aim: To assess the association between inflammation and ED in CHF. Material and methods: Forty two patients aged 56±14 years (80% male) with a CHF in functional capacity II-III (New York Heart Association) and an ejection fraction (EF) <40% were consecutively studied. Patients were classified according to the presence or absence of ED, evaluated by reactive vasodilation measured by ultrasound, after brachial artery compression. Circulating levels of highly sensitive C reactive protein (usCRP), tumor necrosis factor ? (TNF?) and interleukin-6 (IL-6) were determined by ELISA. A group of 15 healthy subjects of similar age, were studied as controls. Results: Sixty seven percent of patients had ED. Compared to controls, patients with CHF had higher usCRP (0.58±0.4 and 4.9±7.1 mg/dl respectively, p <0.01) and IL-6 (1.38±0.06 and 3.1±1.7 mg/dl respectively, p <0.01). Compared to patients without ED, patients with CHF and ED had higher levels of usCRP (3.0±0.4 and 6.0±5.7 mg/dl respectively, p <0.01) and TNF? (0.31±0.26 and 1.0±1.1 pg/ml, p =0.02). No differences in IL-6 were found between CHF groups. Conclusions: In CHF patients, the presence of ED was associated with increased levels of inflammatory markers.

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Título de la Revista: REVISTA MEDICA DE CHILE
Volumen: 136
Número: 6
Editorial: Sociedad Médica de Santiago
Fecha de publicación: 2008
Página de inicio: 687
Página final: 693