Myocardial dysfunction in sepsis Disfunción miocárdica en la sepsis

Andresen M.; Regueira T.

Keywords: sepsis, humans, human, pathophysiology, cardiomyopathy, article, cardiomyopathies


Myocardial dysfunction appears in 25% of patients with severe sepsis and in 50% of patients with septic shock, even in the presence of hyper dynamic states. It is characterized by a reduction in left ventricle ejection fraction, that reverts at the seventh to tenth day of evolution. Right ventricular dysfunction and diastolic left ventricular dysfunction can also appear. There is no consensus if an increase in end diastolic volume is part of the syndrome. High troponin or brain natriuretic peptide levels are associated with myocardial dysfunction and a higher mortality. The pathogenesis of myocardial dysfunction is related to micro and macro circulatory changes, inflammatory response, oxidative stress, intracellular calcium management disturbances, metabolic changes, autonomic dysfunction, activation of apoptosis, mitochondrial abnormalities and a derangement in catecholaminergic stimulation. Since there is no specific treatment for myocardial dysfunction, its management requires an adequate multi systemic support to maintain perfusion pressures and systemic flows sufficient for the regional and global demands.

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Título de la Revista: REVISTA MEDICA DE CHILE
Volumen: 138
Número: 7
Editorial: Sociedad Médica de Santiago
Fecha de publicación: 2010
Página de inicio: 888
Página final: 896