CRF-BP and SLC6A4 gene polymorphisms among restrained eaters Asociación de polimorfismos de los genes CRF-BP, SLC6A4 y restricción alimentaria crónica: Un estudio preliminar

Sanhueza J.A.; Herrera C.L.; Salazar, L.A.; Silva, J. R.

Keywords: disorder, proteins, membrane, transport, polymorphism, serotonin, binding, factor-binding, plasma, protein, gene, risk, humans, human, genetics, disorders, frequency, transporter, adult, female, carrier, control, article, factor, eating, adolescent, young, genetic, case-control, psychological, factors, studies, aspect, study, slc6a4, case, Polymorphism,, protein,, corticotropin, Releasing


Background: Restrained eaters (RE) are a group of individuals who constantly restrict their eating. However, they usually alternate restriction with periods of overeating. Aim: To evaluate the possible association of CRF-BP and SLC6A4 gene polymorphisms with chronic alimentary restriction. Material and Methods: The Spanish version of the Revised Restraint Scale was applied to 132 women aged 18 to 25 years. They were divided in a group classifi ed as restrained eaters (RE) and a group of unrestrained eaters. The 5-HTTLPR and CRF-BPs11 polymorphisms of the SLC6A4 and CRF-BP genes were evaluated by polymerase chain reaction (PCR) and PCR-restriction fragment length polymorphism (RFLP), respectively. Results: There was a signifi cant association between the s/s homozygous genotype for the 5-HTTLPR polymorphism of SLC6A4 gene and RE condition (p = 0.033). However, this association was not observed for the CRF-BPs11 polymorphism. Conclusions: The presence of s/s genotype is associated with the RE condition, being the presence of a s allele, a risk factor for this condition.

Más información

Título de la Revista: REVISTA MEDICA DE CHILE
Volumen: 139
Número: 10
Editorial: Sociedad Médica de Santiago
Fecha de publicación: 2011
Página de inicio: 1261
Página final: 1268